Senior Director, HR Communications and Project Management

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Senior Director, HR Communications & Project Management

Location: Waltham, MA or Conshohocken, PA

Department: Human Resources

Role Type: Full-Time
 

Madrigal is seeking an experienced and strategic Senior Director, HR Communications to lead the development, integration, and execution of a comprehensive communications framework that advances our HR strategic agenda. This leader will partner closely with the CHRO, HR leadership team, and Corporate Communications to ensure clear, consistent, and compelling internal messaging that strengthens understanding of business priorities, enhances organizational culture, and supports employees through periods of growth and change.

The ideal candidate brings deep experience operating in a corporate environment as a communications business partner or functional partner, with a track record of shaping narrative, managing complex stakeholder needs, and translating strategy into actionable communication plans. This individual will serve as the communications “center of excellence” for HR elevating the employee experience, strengthening engagement, and helping position Madrigal as a great place to work.
 

Key Responsibilities

Strategic Leadership & Framework Development

• Develop and implement a holistic HR communications strategy aligned with Human Resources and enterprise priorities.
• Build a multi-layered strategic communications framework that ties together HR initiatives (e.g., Workplace, talent, culture, D&I, leadership development, performance, total rewards, ESG) with clear messaging, storytelling, and measurable outcomes.
• Serve as a trusted advisor to the CHRO and HR Leadership Team, providing insights, messaging guidance, and strategic counsel on communications risks and opportunities.

Communications Planning & Execution

• Lead the creation of content and campaigns that communicate the HR vision, initiatives, and change management activities to employees at all levels.
• Partner with Corporate Communications to ensure messaging alignment with broader organizational communications and brand voice.
• Develop communication strategies for HR programs, including organizational announcements, policy rollouts, new HR technology, culture initiatives, and leadership communications.
• Craft executive-ready materials including talking points, presentations, scripts, leadership emails, intranet content, and Q&A documents.
• Oversee consistent narrative development across channels: email, leader toolkits, town halls, intranet, video, digital platforms, and manager communications.

Cross-functional Collaboration

• Act as the primary communications partner for the CHRO’s direct staff, shaping communication plans for key HR workstreams.
• Coordinate with Corporate Communications, Employee Experience, IT, and business leadership to ensure communications alignment and optimal distribution.
• Train and support HR and people leaders on effective communication practices and change adoption.

Change Management & Organizational Alignment
 

• Partner with HR leaders to drive change communications for Real Estate & Facility matters, talent initiatives, organizational transformations, employee programs, and enterprise-wide changes.
• Ensure employees understand and are engaged with strategic HR and organizational priorities.
• Anticipate information needs and design proactive communications that minimize confusion and increase clarity.

Team Leadership & Operations

• Lead and develop a small team or matrixed contributors to deliver high-quality communications support.
• Create a consistent operating rhythm for HR communications (calendars, templates, dashboards, reporting).
• Establish metrics to measure communication effectiveness and continuously enhance approaches.

Qualifications

Required

• Bachelor’s degree in Communications, Human Resources, Business, or related field; Master’s preferred.
• 10+ years of progressive corporate communications experience, including serving as a communications partner to business or functional executives.
• Demonstrated success creating and executing communication strategies for complex, multi-stakeholder environments.
• Experience supporting HR functions or people-related initiatives (e.g., culture change, talent programs, organizational development, transformation).
• Exceptional writing, storytelling, and editing skills with the ability to simplify complex information.
• Strong executive presence and the ability to influence senior leaders with confidence.
• Proven ability to manage sensitive information with discretion and sound judgment.

Preferred

• Experience in biotech, pharmaceuticals, or other highly regulated environments.
• Expertise in change management methodologies and employee engagement strategies.
• Ability to thrive in a fast-paced, growth-oriented organization.

Leadership Attributes

• Strategic thinker with strong situational awareness
• Highly collaborative and skilled at building trusted relationships
• Comfortable navigating ambiguity and driving clarity
• Detail-oriented communicator with a bias toward action
• Passion for elevating the employee experience and leadership communications

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands.  As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $243,000 - $297,000 per year.  We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com.