Senior Director, Global Scientific Content

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Senior Director of Global Scientific Content is responsible for leading the development and execution of scientific content within Madrigal Medical Affairs. This role contributes to the Medical Affairs and Scientific Communication Plans, ensuring the globalization and alignment of content initiatives.

The Senior Director partners closely with Medical Affairs colleagues to deliver high-quality, impactful scientific content that support both internal stakeholders (e.g., Field Medical, Health Systems) and external stakeholders (e.g., healthcare professionals). These efforts enable effective scientific exchange and communication with impact. The position reports to the Vice President of Scientific Communications (or assigned delegate) and is a hybrid role (three days per week at Conshohocken, PA).

All incumbents are responsible for following applicable Division & Madrigal policies and procedures.

Key Responsibilities and Primary Activities: 

Approximately half (~40%) of the priorities and effort for this role is spent executing functional priorities and objectives, while the other half (~60%) focuses on providing direction, adapting priorities to achieve strategic objectives and leading the team.

• Strategic Planning and Alignment
  • Define and prioritize global scientific content needs of internal and external stakeholders, including Health Systems content as appropriate
  • Ensure scientific content planning is aligned with Madrigal Medical Affairs strategies and Scientific Communication platforms, as well as the training plans
  • Create and execute the global scientific content plan for the fiscal year, including alignment with the Medical Plan, detailed tactics, interdependencies, ownership, and budget
• Content Development
  • Oversee the creation, adaptation, and distribution of global content across multiple channels to deliver consistent and impactful information for scientific exchange
  • Support the development of comprehensive content strategies that leverage digital and omnichannel approaches to enhance engagement with healthcare professionals (HCPs) and internal stakeholders, ensuring alignment with scientific communication platform within compliance and practice standards
  • Ascertain scientific accuracy, stakeholder relevance, and appropriateness of the various formats utilized across all the scientific content materials
  • Champion unwavering commitment to scientific rigor and data-driven decision-making
• Alignment with Training
  • Ensure alignment with global scientific training program for field medical and other relevant stakeholders, ensuring best in class training on new content
  • Gather key insights and key learnings from the evaluation of the impact of training initiatives by analyzing metrics and feedback, ensuring insights are considered for scientific content
• Team Leadership & Development
  • Lead, inspire, and develop a high-performing global scientific content team, fostering an inclusive culture of scientific excellence, accountability, and collaboration 
  • Provide mentoring, coaching, and growth opportunities to ensure ongoing development of team members and future leaders 
  • Align all global content strategy and execution activities with organizational strategic objectives and tactical imperatives, serving as a key thought leader and advisor within Medical Affairs 
• Cross-functional Collaboration
  • Partner with internal cross-functional and regional teams to align on scientific content priorities
  •  Accountability for the collaboration with external vendors and partners as needed to support content deliverables
  • Contribute to launch readiness and support lifecycle medical affairs activities in alignment with strategic objectives
• Congress & External Engagement
  • Contribute to U.S. and global medical congress activities, as needed, including support for booth content, scientific content and training
• Compliance & Quality
  • Ensure all activities comply with company SOPs, industry standards, and applicable regulations
  • Uphold the highest ethical standards in all external engagements
• Travel Requirement
  • Willingness to travel up to 20% for conferences, various corporate locations, and stakeholder meetings, including overnight trips

Required Qualifications, Skills & Experience:

• Advanced degree in a scientific or healthcare discipline (BSc, MD, PharmD, PhD, DNP, etc.)
• Rich scientific background with a minimum of 15 years of experience in healthcare / clinical practice
• A minimum of 5 years headquarters work and/or Scientific Content experience
• Proven ability to understand, communicate, and translate complex scientific information
• Knowledge of Scientific Content and Communication trends and landscape
• Demonstrated ability to plan, lead and create scientific content
• Emphasis on providing leadership though factual evidence gathering influencing and inspiring cross-functional teams to drive innovation and achieve goals
• Ability to interact and strategize with leadership and stakeholders across the business
• Strong knowledge of US/EU healthcare systems, global regulatory standards (e.g., FDA, CE), and medical affairs compliance standards
• Proficiency in Microsoft Office Suite, virtual communication platforms (e.g., Zoom), and CRM systems (e.g., Veeva)

Preferred Attributes:

• In-depth knowledge of liver disease; experience in cardiometabolic health, or metabolic dysfunction–associated steatohepatitis (MASH)
• Adaptable and proactive in a fast-paced, evolving environment

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $275,000 to $336,000 per year.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com.